Endocrine Abstracts

The problem of the influence of disturbances of Hyper- or Hyponatraemia is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. Electrolyte disbalance affected on the formation of mental disorders, their structure and dynamics in the literature has not been sufficiently studied. Perhaps there are certain factors and patterns of the influence of hypo- and hypernatraemia on mental activity with various lesions of the brain, which requi...

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperati...

Objective: Prospective study of cabergoline effect in newly diagnosed patients with giant invasive prolactinomas.Patients and methods: The study group included 121 patients with giant prolactinomas (tumors larger than 40 mm in size); among them 49 patients had tumors larger than 60 mm in size. 91 male and 30 female aged 16–67 years (median 37) were treated with 0.5–3.5 mg/week (mean 1.5 mg) cabergoline. The treatment period was 6–120 month...

Among tumors of the diencephalic region there are: pituitary adenomas, craniopharyngiomas, gliomas, meningiomas and others. They differ in location, histology, clinic with corresponding hormonal disorders. Emotional disorders in the clinic of tumors of the diencephalic region are revealed in 2–67% by the literature. Emotional disturbances with hormone-active pituitary adenomas there are 30–60%, and with non-functioning pituitary adenomas there are ones less than 6%. ...

Suprasellar craniopharyngiomas (CF) are characterised by a high incidence of involvement of the third ventricle, which determines the risk of hypothalamic obesity (HO). There are no unified diagnostic criteria for HO and its effective treatment. The assessment of pre- and postoperative hypothalamic damage is necessary for the choice of surgical strategy and early therapeutic intervention.Objective: To estimate the incidence and extent of weight gain in a...

Gonadotropinomas secreting biologically active hormones, most commonly follicle-stimulating hormone (FSH), are a very rare pathology. The clinical manifestations depend on the gender and age of the patient. Men may observe enlarged testicles and erectile dysfunction. Reports on the results of the drug treatment are sporadic.Objective: To describe a rare clinical case of an active giant FSH-secreting pituitary tumour in a 62-year-old man with the developm...

Reset osmostat syndrome (ROS) is characterized by a change of normal plasma osmolality level (decrease or increase), which leads to chronic dysnatremia (hypo- or hypernatremia). We have described a Clinical case of ROS and chronic hyponatremia in a patient with chordoid glioma of the III ventricle. It is known that the patient had previously been diagnosed with hyponatremia (131-134 mmol/l). She has not hypothyroidism and hypocorticism. There is normal filtration function of t...

Objective: To study the clinical, diagnostic and morphological characteristics and treatment outcomes of TSH-secreting pituitary tumors.Patients and methods: The study included 21 patients with pituitary adenoma and a normal or elevated TSH level and elevated fT4 and fT3 levels who were operated on at the Neurosurgical Institute in the period between 2002 and 2015. Before surgery, in the early postoperative period, and 6 months afte...